The Government’s Environment Policy Index Impact on Recycler Behavior in Electronic Products Closed-Loop Supply Chain

We establish the model of multilevel closed-loop supply chain (CLSC) which included raw material supplier, manufacturer, distributor, retailer, and third-party recycler based on system dynamics (SD). Considering factors which influence recycler behavior-environmental policy index and recovery delay, we apply SD software—Vensim—to simulate CLSC model and study recycler behavior’s influence on the entire CLSC through calculating the bullwhip effect of all levels members order rate. Research shows that (1) the larger the environmental policy index, the greater the recycle proportion and the better the effect of weakening retailer’s order rate in forward supply chain, which however, increasingly, strengthen the reverse supply chain bullwhip effect, (2) the shorter the recovery delay, the better the effect of weakening the forward supply chain bullwhip effect and the longer the recovery delay, which increasingly weakens the reverse supply chain bullwhip effect, and (3) the effect of environmental policy index on the bullwhip effect of all levels members order rate is more significant than recovery delay

The boomerang returns? Accounting for the impact of uncertainties on the dynamics of remanufacturing systems

Recent years have witnessed companies abandon traditional open-loop supply chain structures in favour of closed-loop variants, in a bid to mitigate environmental impacts and exploit economic opportunities. Central to the closed-loop paradigm is remanufacturing: the restoration of used products to useful life. While this operational model has huge potential to extend product life-cycles, the collection and recovery processes diminish the effectiveness of existing control mechanisms for open-loop systems. We systematically review the literature in the field of closed-loop supply chain dynamics, which explores the time-varying interactions of material and information flows in the different elements of remanufacturing supply chains. We supplement this with further reviews of what we call the three ‘pillars’ of such systems, i.e. forecasting, collection, and inventory and production control. This provides us with an interdisciplinary lens to investigate how a ‘boomerang’ effect (i.e. sale, consumption, and return processes) impacts on the behaviour of the closed-loop system and to understand how it can be controlled. To facilitate this, we contrast closed-loop supply chain dynamics research to the well-developed research in each pillar; explore how different disciplines have accommodated the supply, process, demand, and control uncertainties; and provide insights for future research on the dynamics of remanufacturing systems

Research on the Influencing Mechanism of Paradoxical Leadership on Unethical Pro-Supervisor Behavior

Paradoxical leadership is a leadership style that combines both employees’ individual needs and organizational requirements. The existing literature shows that paradoxical leadership has a positive influence on variables at the individual level, team level and organizational level. It is necessary to further explore the negative impact of paradoxical leadership on the individual level (such as employees’ unethical pro-supervisor behavior), the path of influence and situational conditions. Based on social exchange theory, this paper studied the influence of paradoxical leadership on employees’ unethical pro-supervisor behavior, and clarified the mediating role of supervisor–subordinate Guanxi and the moderating effect of follower mindfulness. We conducted an empirical analysis on the data of 356 employees collected in two phases, and found that paradoxical leadership exerts a significant positive effect on unethical pro-supervisor behavior; supervisor–subordinate Guanxi has a partial mediating effect on the relationship between paradoxical leadership and unethical pro-supervisor behavior; and follower mindfulness moderates the influence of paradoxical leadership on supervisor–subordinate Guanxi, and moderates the intermediation of supervisor–subordinate Guanxi on the main effect. This paper enriches the existing research on the mechanism of influence of paradoxical leadership and deepens our understanding of boundary conditions in relation to the role of paradoxical leadership

Senescence Inducer Shikonin ROS-Dependently Suppressed Lung Cancer Progression

Lung adenocarcinoma (LAC), predominant subclassfication of lung cancer, leads high incidence and mortality annually worldwide. During the premalignant transition from lung adenomas to LAC, cellular senescence is regard as a critical physiological barrier against tumor progression. Nevertheless, the role of senescence in tumorigenesis is controversial and few senescence inducers are extensively determined. In this study, we used two classical cell lines A549 and H1299 and two NSCLC xenograft models on Balb/c-nude mice to reveal the pro-senescence effects of shikonin and the corresponding underlying mechanism in LAC. Shikonin, a pure compound isolated from the herbal medicine Lithospermum erythrorhizon, remarkably stimulated cellular senescence including increased SAHF formation, enlarged cellular morphology, and induced SA-β-Gal positive staining. Further mechanism study revealed that the pro-senescence effect of shikonin was dependent on the increased intercellular ROS generation, which subsequently triggered DNA damage-p53/p21waf axis without activating oncogenes such as Ras and MEK-1. Meanwhile, Kdm2b, an H3K36me2-specific demethylase effectively suppressed ROS generation, was also notably suppressed by shikonin treatment. Moreover, shikonin at 10 mg/kg significantly inhibited tumor weights by 55.84% and 50.98% in A549 and H1299 xenograft model, respectively (P < 0.05) through activating cellular senescence. Our study suggested that shikonin, a ROS-dependent senescence inducer, could serve as a promising agent for further lung cancer treatment